Category Archives: Mood Disorders

Incidence, prevalence and clinical correlates of antidepressant-emergent mania in bipolar depression: a systematic review and meta-analysis. – PubMed – NCBI

https://www.ncbi.nlm.nih.gov/pubmed/29441650

Antidepressants in bipolar depression: yes, no, maybe? | Evidence-Based Mental Health

http://ebmh.bmj.com/content/18/4/100.full

Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial – The Lancet

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)30295-2/fulltext?rss=yes For us, this compares the UBC and MDA groups doing TMS in the Lower Mainland. Looks like both work equally well.

antidepressants for insomnia: the highest evidence thus far.

http://cochranelibrary-wiley.com/doi/10.1002/14651858.CD010753.pub2/epdf/abstract basically trazodone and doxepin are reasonable alternatives to z drugs

Chief complaint: Homicidal. Assessing violence risk | MDedge Psychiatry

https://www.mdedge.com/psychiatry/article/164162/chief-complaint-homicidal-assessing-violence-risk?oc_slh=a195008f33c4dd0dfa3c16ad9377076b1fbb3e1fab07e5a2e358c01ae920b082&utm_source=News_CPN_eNL_052518_F&utm_medium=email&utm_content=Is your patient likely to become violent?

POEM: Nonopioids equivalent to opioids for severe chronic back, hip, or knee pain with fewer adverse outcomes

Begin forwarded message: From: “Joule – a CMA Company” <cma.ca> Subject: POEM: Nonopioids equivalent to opioids for severe chronic back, hip, or knee pain with fewer adverse outcomes Date: May 15, 2018 at 4:00:03 AM PDT To: “Joris Anton Josef Wiggers” <joriswiggers> Reply-To: cma.ca View the Web version POEMs Research Summaries Your daily update for […]
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J Clin Psychiatry/Ketamine for Depression, 1: Clinical Summary of Issues Related to Efficacy, Adverse Effects, and Mechanism of Action

http://www.psychiatrist.com/JCP/article/Pages/2017/v78n04/v78n0408.aspx Great ketamine summary

Intranasal Ketamine Succeeds for Resistant Depression

https://www.medscape.com/viewarticle/896510?nlid=122292_329&src=WNL_mdplsnews_180511_mscpedit_psyc&uac=27343DV&spon=12&impID=1630260&faf=1#vp_3 Timeline for S-ketamine intranasal spray, (Janssen), could file for product release by end of the year. Great hype. Low side effects. Good Phase 3 trial data released this month. We are hopeful to use it within 1 year? Game changer? Biggest psychopharma intro in 50 years? Lots of hype…

Long-term effects of pre-birth exposure to anti-depressants 12 years later — ScienceDaily

ECT Can Be Considered Earlier for Severe Depression, Expert Says | Psychopharmacology

https://psychnews.psychiatryonline.org/doi/full/10.1176/appi.pn.2017.pp11a3 This is a landmark study for treatment of depression: They are now moving the benchmark to third line treatment for ECT; that is, after two failed trials of two antidepressants or one antidepressant and one psychotherapy, patient would go on to ECT. This is very aggressive, but the projected models show distinct improvement in […]
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