Thyroid May Hold the Cognitive Key | Psychiatric Times
Basically, treating dementia with donezepil (a cholinesterase inhibitor) used to be a 50-50 proposition, but now this Taiwanese study showed that having higher T4 levels before treatment predicted response to the drug. This suggests a relationship between thyroid function (and cortisol BTW) and neurodegeneration/dementia. Other studies link dementia to number of general anesthesias and surgery, and another study between obesity and dementia. Dementia remains quite underdiagnosed.