Category Archives: Mood Disorders

Long-term effects of pre-birth exposure to anti-depressants 12 years later — ScienceDaily

ECT Can Be Considered Earlier for Severe Depression, Expert Says | Psychopharmacology This is a landmark study for treatment of depression: They are now moving the benchmark to third line treatment for ECT; that is, after two failed trials of two antidepressants or one antidepressant and one psychotherapy, patient would go on to ECT. This is very aggressive, but the projected models show distinct improvement in […]
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Genetic Test Identifies Best Antidepressant

May 8, 2018 A link to the following Medscape article was sent to you by: joris wiggers May need replcation Genetic Test Identifies Best Antidepressant Medscape Medical News, 2018-05-05 WebMD, LLC 825 Eighth Avenue New York, NY 10019

Examining cognition across bipolar schizophrenia spectrum

Association of Depression and Anxiety Disorders With Autoimmune Thyroiditis: A Systematic Review and Meta-analysis | Anxiety Disorders | JAMA Psychiatry | JAMA Network In a nutshell, if you are depressed or anxious, be sure to have a screen for autoimmune thyroiditis (the overwhelming cause of hypothyroidism in the population). The authors conclude: “Taking as a basis a general 12-month prevalence for depression of 6.6%5,6 and a general 12-month prevalence for anxiety disorders of 18.1%6 in the United […]
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J Clin Psychiatry/Trajectories of Acute Antidepressant Efficacy: How Long to Wait for Response? A Systematic Review and Meta-Analysis of Long-Term, Placebo-Controlled Acute Treatment Trials How long do you wait for AD to work? AT least 3 months.

J Clin Psychiatry/Long-Term Acute-Phase Treatment With Antidepressants, 8 Weeks and Beyond: A Systematic Review and Meta-Analysis of Randomized, Placebo-Controlled Trials The study looked at uncommon question of what happens to people on antidepressants after 8 weeks? We all know AD work, but most studies stop at 8 weeks. This study of >100 studies and tens of thousands of subjects revealed that recovery from depression was likely to happen within 6 months compared to placebo, […]
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J Clin Psychiatry/Switching the Antidepressant After Nonresponse in Adults With Major Depression: A Systematic Literature Search and Meta-Analysis The conclusion that staying on the initial antidepressant and pushing up the dose seems real-world and switching more a pharmaceutical grab and unneccessary stressor for the patient. Often, though, people are not on a med for 6 weeks (nonresponse definition) but 6 months, 6 years….That is a different kettle of fish. So, in sum, […]
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Clozapine and Long-Term Mortality Risk in Patients With Schizophrenia: A Systematic Review and Meta-analysis of Stud ies Lasting 1.1–12.5 Years | Schizophrenia Bulletin | Oxford Academic The fear of clozapine in schizophrenia must be stilled! This study shows that people live longer on it than any other antipsychotic. That is hard to argue. It seems other good things are outweighing the bad effects that clozapine has on the body. I think this is an important article. Wiggers

Alzheimer’s: Biomarkers, not cognition, will now define disorder | MDedge Psychiatry Totally new paradigm: AD is a real disease with clear,measurable, defined molecular findings diagnostic for the condition. We are no longer defining it by symptoms (old school!) but now by PET scanner findings of amyloid in brains. That puts AD in the solid grounds of other medical diseases like HTN, diabetes, cancer, etc. Still […]
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