Author Archives: Dr. Joris Wiggers

Case against use of antidepressants in chronic medical illnesses

Effect of sertraline on depressive symptoms in patients with chronic kidney disease without dialysis dependence: The CAST randomized clinical trial JAMA — | November 09, 2017 Hedayati SS, et al. – The researchers investigated the effect of sertraline on depressive symptoms in patients with chronic kidney disease (CKD) and major depressive disorder (MDD). Compared with […]
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This easier, newer psychotherapy has growing evidence of efficacy in PTSD

A Brief Exposure-Based Treatment vs Cognitive Processing Therapy for Posttraumatic Stress DisorderA Randomized Noninferiority Clinical Trial Denise M. Sloan, PhD1,2; Brian P. Marx, PhD1,2; Daniel J. Lee, PhD1; et alPatricia A. Resick, PhD3 Author Affiliations Article Information JAMA Psychiatry. Published online January 17, 2018. doi:10.1001/jamapsychiatry.2017.4249 Key Points Question Is a brief, exposure-based treatment noninferior to […]
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Transdermal Estradiol and Micronized Progesterone for the Prevention of Depression in the Menopause Transition

This is very interesting for middle-aged women contemplating the risks and benefits of HRT. Perhaps a family history or past history of depression might tip the balance in favor of HRT? https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2668205?utm_source=undefined&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=011618#.Wl7brXb55tg.email — This message was sent by joriswiggers@gmail.com via http://addthis.com. Please note that AddThis does not verify email addresses. To stop receiving any emails […]
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Latest guidelines for treating Alcohol Use Disorder with medications.

Citations from the article as below, in summary: Naltrexone and acamprosate are recommended to treat patients with moderate to severe alcohol use disorder in specific circumstances (e.g., when nonpharmacological approaches have not produced an effect or when patients prefer to use one of these medications). Topiramate and gabapentin are also suggested as medications for patients […]
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Slideshow: Tips for Living Well With Depression

Very nice summary a rticle for those interested in Natural treatments of depression! Enjoy the slide show. https://www.medicinenet.com/depression_tips_pictures_slideshow/article.htm?ecd=mnl_spc_010518 Depression Symptoms: Exercise, Diet & Stress Reduction Reviewed by Joseph Goldberg, MD on Friday, October 09, 2015 Depression Tips: Exercise, Diet, Stress Reduction, and More in Pictures Sources: This tool does not provide medical advice. See additional […]
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Psycho-Pharm Medications with depression as a potential side effect

This is a latest updated article I received from my peers on a psychiatric List-Serv. The review of several medications that CAUSE depression is interesting and important to know.  Steroids can cause depression and mania and psychosis.   Dialogues Clin Neurosci. 2011;13(1):109-25. Depressogenic effects of medications: a review. Celano CM1, Freudenreich O, Fernandez-Robles C, Stern […]
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Mentalization-Based Treatment: A Common-Sense Approach to Borderline Personality Disorder | Psychiatric Times

I wanted to have this readily available: Peter Fonagy, a respected psychoanalyst in the UK has worked very hard in the recent ten years to substantiate the efficacy of psychodynamic psychotherapy for borderline personality disorder. This is his effort. Well worth reading it, as it applies broadly I think to other areas of psychological experience. […]
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S-ketamine intranasal treatment! A new approach to depression…

https://clinicaltrials.gov/show/NCT01998958 Trial data for successfully completed trial of S-ketamine intranasal therapy. Small study, needs replication and safety data. S-ketamine is purported to be safer than mixed enantiomer ketamine (special K).

Association between Bipolar and Borderline Personality features (BPF)

“Of the nine BPF, affective instability, impulsivity, and self-mutilation/suicidality showed a clear relationship to overall mood episode frequency,” according to an article published online in the International Journal of Bipolar Disorders. The nine borderline personality features include avoiding abandonment, interpersonal instability, identity disturbance, self-mutilation/suicidality, affective instability, chronic emptiness, intense anger, paranoid & dissociation, and impulsivity. […]
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The Amazing Mosaic Brain: Neither Male or Female

The amazing mosaic: The Brain Believe it or not, the brain is very (very) complex: no longer does it appear that there are male and female brains; indeed, the latest conversation has failed to identify a clear dichotomy. In fact, each individual has a mosaic of traits classically considered male or female, such that everybody […]
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