Psycho-Pharm Medications with depression as a potential side effect

This is a latest updated article I received from my peers on a psychiatric List-Serv. The review of several medications that CAUSE depression is interesting and important to know.  Steroids can cause depression and mania and psychosis.


Dialogues Clin Neurosci. 2011;13(1):109-25.

Depressogenic effects of medications: a review.

Celano CM1, Freudenreich O, Fernandez-Robles C, Stern TA, Caro MA, Huffman JC.

Author information


The literature is filled with reports that link medications with the onset or progression of depression. Because depression is so common in patients with medical illness, assessing whether a medication has in fact caused depression, or whether the relationship is coincidental, can be challenging. In this article, we review the literature on the association between medications and depression. For most agents, there are case reports or small studies linking the medication with the onset of depression, but more rigorous prospective studies are either lacking or found no association between the agent and depression. However, several medications, (eg, barbiturates, vigabatrin, topiramate, flunarizine, corticosteroids, mefloquine, efavirenz, and interferon-alpha) do appear to cause depression in some patients and should be used with caution in patients at risk for depression.

PMID: 21485751 PMCID: PMC3181967
[Indexed for MEDLINE] Free PMC Article


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