Author Archives: Dr. Joris Wiggers

Incidence, prevalence and clinical correlates of antidepressant-emergent mania in bipolar depression: a systematic review and meta-analysis. – PubMed – NCBI

https://www.ncbi.nlm.nih.gov/pubmed/29441650

Antidepressants in bipolar depression: yes, no, maybe? | Evidence-Based Mental Health

http://ebmh.bmj.com/content/18/4/100.full

Depression and Dysthymia

When the strictest criteria are used to sift through all the research literature on the pharmacological treatment of depression and dysthymia, only using large studies with low bias and meticulously designed trials, interestingly, only two studies since 2000 made the grade (with 90% certainty, using AI algorithm): https://www.ncbi.nlm.nih.gov/pubmed/21154393 https://www.ncbi.nlm.nih.gov/pubmed/8792754 In sum, using sertraline or imipramine does […]
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Association between dietary glycemic index and glycemic load with depression: a systematic review | SpringerLink

https://link.springer.com/article/10.1007/s00394-018-1710-5 Simple sugars and high GI foods make you depressed.

Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial – The Lancet

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)30295-2/fulltext?rss=yes For us, this compares the UBC and MDA groups doing TMS in the Lower Mainland. Looks like both work equally well.

antidepressants for insomnia: the highest evidence thus far.

http://cochranelibrary-wiley.com/doi/10.1002/14651858.CD010753.pub2/epdf/abstract basically trazodone and doxepin are reasonable alternatives to z drugs

Chief complaint: Homicidal. Assessing violence risk | MDedge Psychiatry

https://www.mdedge.com/psychiatry/article/164162/chief-complaint-homicidal-assessing-violence-risk?oc_slh=a195008f33c4dd0dfa3c16ad9377076b1fbb3e1fab07e5a2e358c01ae920b082&utm_source=News_CPN_eNL_052518_F&utm_medium=email&utm_content=Is your patient likely to become violent?

Keep saying yes to fish twice a week for heart health — ScienceDaily

https://www.sciencedaily.com/releases/2018/05/180517081837.htm The advisory was written by a panel of nutrition experts, who also reviewed studies about mercury in fish. Mercury is found in most seafood but is prevalent in large fish such as shark, swordfish, tilefish, king mackerel, bigeye tuna, marlin and orange roughy. The writing group concluded that while mercury contamination may be associated […]
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Smarter brains run on sparsely connected neurons — ScienceDaily

https://www.sciencedaily.com/releases/2018/05/180517102236.htm “Intelligent brains possess lean, yet efficient neuronal connections,” concludes Erhan Genç. “Thus, they boast high mental performance at low neuronal activity.”

Brain abnormality indicates general risk for mental illness: A new study identifies functional connectivity impairments associated with transdiagnostic risk for common forms of mental illness — ScienceDaily

https://www.sciencedaily.com/releases/2018/05/180517102401.htm Authors conclude: “These patterns suggest that broad risk for mental illness may reflect subtle problems in how a person is able to integrate their thoughts, plans, and actions with their fundamental experience of the world, which in humans is principally represented by visual information,” said Mr. Elliott.