The Safety of Stimulant Medication Use in Cardiovascular and Arrhythmia Patients – American College of Cardiology

As of 2015, the American Cardiology Association has been very specific that psychostimulants (RITALIN, ADDERALL), including presumably lesser agents like modafinil, armodafinil, and atomoxetine, all increase the odds 2x of a cardiac event, including Torsade de Pointe, arrhythmias, with special mention for LV hypertrophy and modafinil. The studies are mixed in long term outcomes with actual data limited to case reports, but the conclusion was that even modest rises in BP and HR probably add a risk to future cardiac events, particularly long-term (i.e. over 2 years, where most studies ended), IN patients with established cardiac disease (prior MI, CHF, arrhythmias).

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