Association of Depression and Anxiety Disorders With Autoimmune Thyroiditis: A Systematic Review and Meta-analysis | Anxiety Disorders | JAMA Psychiatry | JAMA Network
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2679767?utm_source=silverchair&utm_campaign=jama_network&utm_content=weekly_highlights&cmp=1&utm_medium=email In a nutshell, if you are depressed or anxious, be sure to have a screen for autoimmune thyroiditis (the overwhelming cause of hypothyroidism in the population). The authors conclude: “Taking as a basis a general 12-month prevalence for depression of 6.6%5,6 and a general 12-month prevalence for anxiety disorders of 18.1%6 in the United […]
Read More »
J Clin Psychiatry/Trajectories of Acute Antidepressant Efficacy: How Long to Wait for Response? A Systematic Review and Meta-Analysis of Long-Term, Placebo-Controlled Acute Treatment Trials
http://www.psychiatrist.com/JCP/article/Pages/2018/v79n03/17r11470.aspx?utm_source=TrendMD&utm_medium=cpc&utm_campaign=Journal_of_Clinical_Psychiatry_TrendMD_0 How long do you wait for AD to work? AT least 3 months.
J Clin Psychiatry/Long-Term Acute-Phase Treatment With Antidepressants, 8 Weeks and Beyond: A Systematic Review and Meta-Analysis of Randomized, Placebo-Controlled Trials
http://www.psychiatrist.com/JCP/article/Pages/2018/v79n01/15r10545.aspx The study looked at uncommon question of what happens to people on antidepressants after 8 weeks? We all know AD work, but most studies stop at 8 weeks. This study of >100 studies and tens of thousands of subjects revealed that recovery from depression was likely to happen within 6 months compared to placebo, […]
Read More »
J Clin Psychiatry/Switching the Antidepressant After Nonresponse in Adults With Major Depression: A Systematic Literature Search and Meta-Analysis
http://www.psychiatrist.com/JCP/article/Pages/2018/v79n01/16r10749.aspx The conclusion that staying on the initial antidepressant and pushing up the dose seems real-world and switching more a pharmaceutical grab and unneccessary stressor for the patient. Often, though, people are not on a med for 6 weeks (nonresponse definition) but 6 months, 6 years….That is a different kettle of fish. So, in sum, […]
Read More »
Clozapine and Long-Term Mortality Risk in Patients With Schizophrenia: A Systematic Review and Meta-analysis of Stud ies Lasting 1.1–12.5 Years | Schizophrenia Bulletin | Oxford Academic
https://academic.oup.com/schizophreniabulletin/advance-article-abstract/doi/10.1093/schbul/sby052/4985581?redirectedFrom=fulltext The fear of clozapine in schizophrenia must be stilled! This study shows that people live longer on it than any other antipsychotic. That is hard to argue. It seems other good things are outweighing the bad effects that clozapine has on the body. I think this is an important article. Wiggers
Alzheimer’s: Biomarkers, not cognition, will now define disorder | MDedge Psychiatry
https://www.mdedge.com/psychiatry/article/163073/alzheimers-cognition/alzheimers-biomarkers-not-cognition-will-now-define/page/0/8?utm_source=PANTHEON_STRIPPED&utm_medium=PANTHEON_STRIPPED&utm_content=PANTHEON_STRIPPED Totally new paradigm: AD is a real disease with clear,measurable, defined molecular findings diagnostic for the condition. We are no longer defining it by symptoms (old school!) but now by PET scanner findings of amyloid in brains. That puts AD in the solid grounds of other medical diseases like HTN, diabetes, cancer, etc. Still […]
Read More »
240mg vit b6 can enhance your dream recall
100 subjects tested vs control group. Noticeable improvement in vividness of dream next day. No side effects. Worked within 5 days of use. University of Adelaide. (2018, April 27). Vitamin B6 helps people recall their dreams. ScienceDaily. Retrieved April 29, 2018 from http://www.sciencedaily.com/releases/2018/04/180427100258.htm
Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial – Clinical Nutrition
https://www.clinicalnutritionjournal.com/article/S0261-5614(18)30161-4/fulltext?rss=yes “One hundred and ten depressed patients were randomly assigned to receive the probiotic (Lactobacillus helveticus and Bifidobacterium longum), prebiotic (galactooligosaccharide) or placebo for 8 weeks.”—authors They were better after the treatment compared to placebo, P<0.05. (Hmmmm, is that good enough?) “Overall, 8 weeks of probiotic supplements to subjects with MDD resulted in an improvement […]
Read More »
Pharmacologic Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia: A Systematic Review. – PubMed – NCBI
https://www.ncbi.nlm.nih.gov/pubmed/29255847?dopt=Abstract “CONCLUSION: Evidence does not support use of the studied pharmacologic treatments for cognitive protection in persons with normal cognition or MCI.”—authors
Dr. Joris Wiggers 