J Clin Psychiatry/Long-Term Acute-Phase Treatment With Antidepressants, 8 Weeks and Beyond: A Systematic Review and Meta-Analysis of Randomized, Placebo-Controlled Trials


The study looked at uncommon question of what happens to people on antidepressants after 8 weeks? We all know AD work, but most studies stop at 8 weeks. This study of >100 studies and tens of thousands of subjects revealed that recovery from depression was likely to happen within 6 months compared to placebo, up to 12 months. The AD group generally did moderately better than the placebo group on standardized assessments. AD are good to do vs. placebo.

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