http://n.neurology.org/content/90/3/126.long Reference article for approach to early signs of cognitive decline. Note: medications have little evidence they work; exercise is best
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2678576?utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamapsychiatry&utm_content=olf&utm_term=042518 “These findings suggest that there is poor integration in the coordinated development of cortical folding in patients who develop psychosis.”—authors
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2678577 As high as 60% of cannabis users will convert to schizophrenia if they start out with mild schizotypal personality features; strong evidence that cannabis moves one along the psychoticism spectrum.
http://lfpress.com/news/local-news/london-scientists-push-envelope-in-combating-opioid-addiction Study showed that D1 blockers protect against PTSD, D4 blockers facilitated PTSD. Amazingly some antipsychotics block D1 and might help protect vs. PTSD (and help at the underlying link between trauma and addiction) Clozapine, Olanzapine are top two. No surprises. Seroquel very low. Surprise. https://ils.unc.edu/bmh/neoref/this.dir.unneeded/schizophrenia/review/tmp/165.pdf
https://www.frontiersin.org/articles/10.3389/fpsyg.2018.00487/full Now THIS is the most important article I have encountered in a long while. IT is some beautifully simple. Micronutrients are needed for brain function and we ain’t getting enough! The processed foods we eat are depleted. I wrote earlier about studies linking low micronutrients to depression and suggested supplements: this is far far […]
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https://www.ncbi.nlm.nih.gov/pubmed/28982659?dopt=Abstract “Remission and recovery rates in FEP may be more favourable than previously thought.”—authors of study.
https://www.biologicalpsychiatryjournal.com/article/S0006-3223(18)30069-6/ppt This is a very interesting article which puts it together (genes and environment) for bipolar, depression, and schizophrenia. Adds to literature on glucocorticoid receptors, heat shock protein, and epigenetic methylation of DNA. FKBP5 is a gene common to all persons which mediates the interaction between stress/adversity and many different psychiatric disorders. This model offers […]
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https://www.ncbi.nlm.nih.gov/pubmed/28181901 Something to consider for any refractory condition in which you might suspect inflammation or infection as the cause. IL-6 or TNFa or hsCRP might be good screens.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016695/ This is a long article but a great read, recommended to me from a respected colleagues. It tries to define delusions (as opposed to ideology, religion, or political position). Good to ponder on a rainy day.
Dr. Joris Wiggers