Metformin had the most evidence of being effective in preventing weight gain (MD −4.03 kg, 95% CI −5.78 to −2.28; 4 studies, N = 131; low-certainty evidence) and increases in body mass index (BMI) (MD −1.63 kg/m2, 95% CI −2.96 to −0.29; 5 studies, N = 227; low-certainty evidence). Other agents that may be slightly effective in preventing weight gain include H2 antagonists such as nizatidine, famotidine, and ranitidine (MD −1.32 kg, 95% CI −2.09 to −0.56; 3 studies, N = 248; low-certainty evidence) and monoamine modulators such as reboxetine and fluoxetine (MD −1.89 kg, 95% CI −3.31 to −0.47; 3 studies, N = 103; low-certainty evidence). Topiramate did not appear effective in preventing weight gain (MD −4.82 kg, 95% CI −9.99 to 0.35; 3 studies, 168 participants; very low-certainty evidence).

Abstract Summary

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sbad037.pdf