This is the beginning of 21st century treatment of depression: I am hopeful we can find cortical structures that have been shrunk (i.e. in a way, injured) by a severe depression, in order to neuromodulate them (with rTMS, ECT, or TCMS) to repair it.

https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2675370?utm_source=undefined&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=032818#.WrxsFvRNvfI.email

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