Lancet Commission on the prevention of dementia focuses on 9 risk factors: they suggestion modifying the following: low education, midlife hearing loss, obesity, hypertension, late-life depression, smoking, physical inactivity, diabetes, and social isolation. Yet, this only controls 33% of the variance determining onset of dementia later in life. There are no conclusive treatments still.

There are thus three intervention “classes”: cognitive training, physical exercise, and blood pressure management in hypertension.

AMA Intern Med. 2018;178(2):281-282. doi:10.1001/jamainternmed.2017.7299