Calorie restriction trial in humans suggests benefits for age-related disease https://www.sciencedaily.com/releases/2018/03/180322141008.htm

One of the first studies to explore the effects of calorie restriction on humans showed that cutting caloric intake by 15 percent for two years slowed aging and metabolism and protected against age-related disease. The study found that calorie restriction decreased systemic oxidative stress, which has been tied to age-related neurological conditions such as Alzheimer’s and Parkinson’s diseases, as well as cancer, diabetes, and others.